This retrospective study looked at 22 adult patients who had confirmed PSC and IBD and who had been on oral vancomycin for a period of time.

15 of the 22 patients (68.2%) had less therapy intensification on oral vancomycin therapy compared to off oral vancomycin therapy. There were also less steroid prescriptions for those taking oral vancomycin.

This suggests that oral vancomycin may be an effective therapy for controlling IBD in patients with PSC and IBD.