This case study reports on a 15 year old girl with PSC and ulcerative colitis. After taking oral vancomycin, the girl achieved normalization of her liver numbers and bile ducts, resolution of UC symptoms, and colonic mucosal healing.

The investigators believe the vancomycin may be acting both as an antibiotic (by altering the intestinal microbiome) and as an immunomodulator (by modulating the immune system).