This retrospective study looked at 22 adult patients who had confirmed PSC and IBD and who had been on oral vancomycin for a period of time. 15 of the 22 patients (68.2%) had less therapy intensification on oral vancomycin therapy compared to off oral vancomycin therapy. There were also less steroid prescriptions for those taking […]
Role of Oral Vancomycin in Inducing Remission for Biologic Experienced Ulcerative Colitis With Concomitant Primary Sclerosing Cholangitis and Liver Transplantation
This case report follows a PSC patient who had severe ulcerative colitis after a liver transplant who did not respond to Entyvio or Remicade. This 51-year old man ended up finding remission with oral vancomycin. The authors’ final sentence in this report states that in cases of severe ulcerative colitis, surgery can be curative—but surgery […]
Oral Vancomycin Induced and Maintained Clinical and Endoscopic Remission in Ulcerative Colitis and Primary Sclerosing Cholangitis Post-liver Transplantation
This case study followed a 34-year-old man with PSC and ulcerative colitis who did not respond to multiple advanced therapies, and who had a liver transplant. Before his liver transplant, he tried mesalamine and Remicade without achieving remission. After his liver transplant, his UC flared and he tried Remicade, Entyvio, Humira, Xeljanz, and Stelara. However, […]
Complete Biochemical Remission With Oral Vancomycin in a Patient With Primary Sclerosing Cholangitis and High Serum Immunoglobulin G4 Levels
This case study follows a 20-year old young man with ulcerative colitis and elevated AST, ALT, Alkaline Phosphatase, and IgG4, as well as narrowed bile ducts and liver inflammation and fibrosis. While steroids lowered his liver enzymes in the him short-term, they increased when he tapered off, so he was prescribed oral vancomycin (OV) at […]
How Frequent Are Vancomycin-Resistant Enterococci in patients with Primary Sclerosing Cholangitis and Ulcerative Colitis Treated With Oral Vancomycin?
This study followed seven adult patients with both PSC and ulcerative colitis. All patients were treated for at least six months with oral vancomycin doses between 250 mg – 1,500 mg per day. All patients achieved clinical remission with their ulcerative colitis. Labs that decreased included: fecal calprotectin, C-reactive protein, the Mayo score, alkaline phosphatase, […]
A Triple Blinded, Randomized, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis: A Pilot Study
This 12-week study was a triple blinded, randomized, placebo-controlled trial performed on 29 patients in Iran. 11 patience were randomly assigned the placebo and 18 patients were treated with oral vancomycin (125 mg, four times a day) The vancomycin group showed a decrease in their alkaline phosphatase, sedimentation rate, GGT, and the Mayo Risk Score. […]