This 12-week study was a triple blinded, randomized, placebo-controlled trial performed on 29 patients in Iran. 11 patience were randomly assigned the placebo and 18 patients were treated with oral vancomycin (125 mg, four times a day) The vancomycin group showed a decrease in their alkaline phosphatase, sedimentation rate, GGT, and the Mayo Risk Score. […]
Effects of Antibiotic Therapy in Primary Sclerosing Cholangitis with and without Inflammatory Bowel Disease
This paper reviews the results of five studies that investigated the use of antibiotics (vancomycin, metronidazole, rifaximin, and minocycline) in 124 PSC patients. Specifically, this paper analyzes the impacts of the antibiotics on the following biomarkers: Mayo PSC Risk Score (MRS), ALP, total serum bilirubin, and adverse events.
Open-Label Prospective Therapeutic Clinical Trials: Oral Vancomycin in Children and Adults with Primary Sclerosing Cholangitis
This research paper documents the impacts of oral vancomycin on the GGT, ALP, and ALT of 59 PSC patients. If patients weighed less than 30 kg, they took 50 mg vancomycin per kg each day. If patients weighed more than 30 kg, they took 500 mg vancomycin 3x each day. 96% experienced reduction of GGT, […]