In this 12-week pilot study, 35 adult PSC patients were randomized into one of 4 groups: 1. 125 mg oral vancomycin 4x/day 2. 250 mg oral vancomycin 4x/day 3. 250 mg metronizadole 3x/day 4. 500 mg metronizadole 3x/day One goal of this study was to investigate the safety and efficacy of these drugs. Another goal […]
Effects of Antibiotic Therapy in Primary Sclerosing Cholangitis with and without Inflammatory Bowel Disease
This paper reviews the results of five studies that investigated the use of antibiotics (vancomycin, metronidazole, rifaximin, and minocycline) in 124 PSC patients. Specifically, this paper analyzes the impacts of the antibiotics on the following biomarkers: Mayo PSC Risk Score (MRS), ALP, total serum bilirubin, and adverse events.