This case report shares the positive changes in the microbiome after a nine-year-old by took vancomycin for 90 days. Thanks to vancomycin, his ulcerative colitis symptoms resolved, his fecal calprotectin normalized, and his GGT (a liver function test that helps monitor PSC) declined and returned to normal levels!
Effects of Antibiotic Therapy in Primary Sclerosing Cholangitis with and without Inflammatory Bowel Disease
This paper reviews the results of five studies that investigated the use of antibiotics (vancomycin, metronidazole, rifaximin, and minocycline) in 124 PSC patients. Specifically, this paper analyzes the impacts of the antibiotics on the following biomarkers: Mayo PSC Risk Score (MRS), ALP, total serum bilirubin, and adverse events.
Successful Response of Primary Sclerosing Cholangitis and Associated Ulcerative Colitis to Oral Vancomycin May Depend on Brand and Personalized Dose
This case report shares that a 23-year old female has been taking vancomycin for PSC for eight years, and achieved normalization of liver enzymes and resolution of UC symptoms with colonic mucosal healing. There has been no colon dysplasia, liver fibrosis or failure, bile duct stricture, or cancer. However, the patient experienced worsening symptoms when […]
“Living With PSC” Podcast, Episode 14: Vancomycin as a treatment for PSC, Featuring Dr. James Tabibian
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