This study followed seven adult patients with both PSC and ulcerative colitis. All patients were treated for at least six months with oral vancomycin doses between 250 mg – 1,500 mg per day. All patients achieved clinical remission with their ulcerative colitis. Labs that decreased included: fecal calprotectin, C-reactive protein, the Mayo score, alkaline phosphatase, […]
Dr. Ken Cox Presentation with Cincinnati Children’s Hospital: Treatment of Pediatric PSC with Oral Vancomycin
In this presentation, Dr. Ken Cox—the doctor who discovered the use of oral vancomycin for PSC—shares an enlightening presentation on this matter. Topics included are: • Dr. Cox’s experience treating children with PSC with oral vancomycin • Possible mechanisms in which oral vancomycin treats PSC • Long-term treatment of oral vancomycin • Effect of oral […]
Randomised Clinical Trial: Vancomycin or Metronidazole in Patients with Primary Sclerosing Cholangitis: A Pilot Study
In this 12-week pilot study, 35 adult PSC patients were randomized into one of 4 groups: 1. 125 mg oral vancomycin 4x/day 2. 250 mg oral vancomycin 4x/day 3. 250 mg metronizadole 3x/day 4. 500 mg metronizadole 3x/day One goal of this study was to investigate the safety and efficacy of these drugs. Another goal […]
A Triple Blinded, Randomized, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis: A Pilot Study
This 12-week study was a triple blinded, randomized, placebo-controlled trial performed on 29 patients in Iran. 11 patience were randomly assigned the placebo and 18 patients were treated with oral vancomycin (125 mg, four times a day) The vancomycin group showed a decrease in their alkaline phosphatase, sedimentation rate, GGT, and the Mayo Risk Score. […]
“Aviva’s Story, Part One: The Drive to Have Children” on The Healthful Woman Podcast
Listen to the empowering story of Aviva—a woman living with PSC and myasthenia gravis. She takes oral vancomycin to manage her PSC and, because of this, she received her doctor’s blessing to try for a family. If you’re considering family planning with PSC, this episode will be an inspiring one as it highlights the power […]
Oral Vancomycin Therapy in a Child with Primary Sclerosing Cholangitis and Severe Ulcerative Colitis
This case study reports on a 15 year old girl with PSC and ulcerative colitis. After taking oral vancomycin, the girl achieved normalization of her liver numbers and bile ducts, resolution of UC symptoms, and colonic mucosal healing. The investigators believe the vancomycin may be acting both as an antibiotic (by altering the intestinal microbiome) […]