This retrospective chart review looked at six PSC patients who had active ulcerative colitis and who had failed standard treatments including mesalamine, immunomodulators, and biologics. Within six weeks of starting oral vancomycin, all six patients found clinical remission and maintained remission for two years of follow-up. They also had improved liver numbers. Read the full […]
Role of Oral Vancomycin in Inducing Remission for Biologic Experienced Ulcerative Colitis With Concomitant Primary Sclerosing Cholangitis and Liver Transplantation
This case report follows a PSC patient who had severe ulcerative colitis after a liver transplant who did not respond to Entyvio or Remicade. This 51-year old man ended up finding remission with oral vancomycin. The authors’ final sentence in this report states that in cases of severe ulcerative colitis, surgery can be curative—but surgery […]
Vancomycin and Ustekinumab Combination Therapy in Acute Ulcerative Colitis
This is an interesting case report that shows that the combination therapy of oral vancomycin and ustekinumab (Stelara) put a 25-year old PSC-UC patient into remission with her ulcerative colitis. Ultimately, the authors conclude that, in patients with ulcerative colitis, oral vancomycin may change the microbiome in a way that improves dysbiosis and reduces inflammation […]
Coexisting Primary Sclerosing Cholangitis and Autoimmune Hepatitis: Overlapping Challenges in Diagnosis and Treatment
This 2024 case report discusses a patient with ulcerative colitis, PSC, and autoimmune hepatitis who responded well to oral vancomycin. This 30-year old woman went to the hospital with abdominal pain, bloody diarrhea, and vomiting bile. She tried multiple treatment regimens, but the only one that was effective was oral vancomycin. This insightful case report […]
Oral Vancomycin Induces, Maintains Remission of UC in Patients with UC-PSC
This article shares the insights of a study presented at Digestive Disease Week in 2019. This retrospective chart review is “the largest case study to date to examine oral vancomycin in patients with UC-PSC.” This research showed that “oral vancomycin safely induced and maintained remission of ulcerative colitis among a subset of patients with ulcerative […]
Ulcerative Colitis Pipeline Insight 2024 | FDA Approvals, Clinical Trials, and Therapies
This press release shares data gathered by DelveInsight—a healthcare-focused market research and consulting firm. This article is super exciting and hopeful, as it shows some promising IBD therapies in the pipeline, from pills to subcutaneous injections to IV biologics. One of the therapies listed under “promising ulcerative colitis therapies” is oral vancomycin! I believe there’s […]