This case study followed a 34-year-old man with PSC and ulcerative colitis who did not respond to multiple advanced therapies, and who had a liver transplant. Before his liver transplant, he tried mesalamine and Remicade without achieving remission. After his liver transplant, his UC flared and he tried Remicade, Entyvio, Humira, Xeljanz, and Stelara. However, […]
Complete Biochemical Remission With Oral Vancomycin in a Patient With Primary Sclerosing Cholangitis and High Serum Immunoglobulin G4 Levels
This case study follows a 20-year old young man with ulcerative colitis and elevated AST, ALT, Alkaline Phosphatase, and IgG4, as well as narrowed bile ducts and liver inflammation and fibrosis. While steroids lowered his liver enzymes in the him short-term, they increased when he tapered off, so he was prescribed oral vancomycin (OV) at […]
How Frequent Are Vancomycin-Resistant Enterococci in patients with Primary Sclerosing Cholangitis and Ulcerative Colitis Treated With Oral Vancomycin?
This study followed seven adult patients with both PSC and ulcerative colitis. All patients were treated for at least six months with oral vancomycin doses between 250 mg – 1,500 mg per day. All patients achieved clinical remission with their ulcerative colitis. Labs that decreased included: fecal calprotectin, C-reactive protein, the Mayo score, alkaline phosphatase, […]
Microbiome Responses to Vancomycin Treatment in a Child With Primary Sclerosing Cholangitis and Ulcerative Colitis
This case report shares the positive changes in the microbiome after a nine-year-old by took vancomycin for 90 days. Thanks to vancomycin, his ulcerative colitis symptoms resolved, his fecal calprotectin normalized, and his GGT (a liver function test that helps monitor PSC) declined and returned to normal levels!
Oral Vancomycin Therapy in a Child with Primary Sclerosing Cholangitis and Severe Ulcerative Colitis
This case study reports on a 15 year old girl with PSC and ulcerative colitis. After taking oral vancomycin, the girl achieved normalization of her liver numbers and bile ducts, resolution of UC symptoms, and colonic mucosal healing. The investigators believe the vancomycin may be acting both as an antibiotic (by altering the intestinal microbiome) […]
Oral Vancomycin Induces Sustained Deep Remission in Adult Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis
This paper is a collection of three brief case reports that describes the effect of oral vancomycin treatment in three patients with UC and PSC. All three patients achieved clinical remission and mucosal healing with vancomycin. The patients took 500 mg twice a day. Maintenance treatment with oral vancomycin led to sustained clinical and endoscopic […]