In this retrospective study, the Paediatric PSC Consortium compared the health of patients with PSC and IBD who had taken oral vancomycin (OV) to PSC-IBD patients who had not taken OV. Out of 113 patients with PSC-IBD, 70 were treated with OV, and they had a better chance of their IBD going into remission compared […]
Microbiome Responses to Vancomycin Treatment in a Child With Primary Sclerosing Cholangitis and Ulcerative Colitis
This case report shares the positive changes in the microbiome after a nine-year-old by took vancomycin for 90 days. Thanks to vancomycin, his ulcerative colitis symptoms resolved, his fecal calprotectin normalized, and his GGT (a liver function test that helps monitor PSC) declined and returned to normal levels!
“Living With PSC” Online Forum and Support Community
Countless stories have been shared and questions have been answered in this incredible online forum. This is a great place to find community and learn about others’ experiences with PSC, vancomycin, transplants, symptoms, and so much more.
Oral Vancomycin Induces Sustained Deep Remission in Adult Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis
This paper is a collection of three brief case reports that describes the effect of oral vancomycin treatment in three patients with UC and PSC. All three patients achieved clinical remission and mucosal healing with vancomycin. The patients took 500 mg twice a day. Maintenance treatment with oral vancomycin led to sustained clinical and endoscopic […]
Effects of Antibiotic Therapy in Primary Sclerosing Cholangitis with and without Inflammatory Bowel Disease
This paper reviews the results of five studies that investigated the use of antibiotics (vancomycin, metronidazole, rifaximin, and minocycline) in 124 PSC patients. Specifically, this paper analyzes the impacts of the antibiotics on the following biomarkers: Mayo PSC Risk Score (MRS), ALP, total serum bilirubin, and adverse events.
Open-Label Prospective Therapeutic Clinical Trials: Oral Vancomycin in Children and Adults with Primary Sclerosing Cholangitis
This research paper documents the impacts of oral vancomycin on the GGT, ALP, and ALT of 59 PSC patients. If patients weighed less than 30 kg, they took 50 mg vancomycin per kg each day. If patients weighed more than 30 kg, they took 500 mg vancomycin 3x each day. 96% experienced reduction of GGT, […]