This research paper documents the impacts of oral vancomycin on the GGT, ALP, and ALT of 59 PSC patients. If patients weighed less than 30 kg, they took 50 mg vancomycin per kg each day. If patients weighed more than 30 kg, they took 500 mg vancomycin 3x each day.

96% experienced reduction of GGT, 81.3% experienced reduction of ALP, and 94.9% experienced reduction of ALT, respectively. Overall, vancomycin was well-tolerated and was associated with improvement in liver chemistry.